Bioinformatics Scientist Job at 燃石医学 Burning Rock Biotech, Irvine, CA

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  • 燃石医学 Burning Rock Biotech
  • Irvine, CA

Job Description

About Burning Rock Dx.:

Burning Rock Dx. (NASDAQ:BNR) was foundedin 2014, and it is a leading innovator in next-generation sequencing (NGS) technologies, dedicated to advancing precision medicine, genomics research, and clinical diagnostics. We collaborate with global partners to deliver cutting-edge solutions for complex biological challenges.

About the Role:

We‘re seeking a highly skilled and motivated Clinical Bioinformatics Scientist to join our CAP-accredited molecular oncology laboratory. The candidate will play a crucial role in analyzing and interpreting Next-Generation Sequencing (NGS) data for cancer diagnostics, ensuring compliance with CLIA/CAP guidelines, and contributing to the development of robust bioinformatics pipelines for somatic and germline variant analysis.

Key Responsibilities:

  • Analyze and interpret NGS data for molecular oncology applications, including somatic and germline variant calling, copy number alterations, structural variations, and tumor mutational burden (TMB)/microsatellite instability (MSI) analysis .
  • Develop, optimize, and maintain bioinformatics pipelines for clinical NGS testing, ensuring compliance with CAP, CLIA, and FDA regulatory requirements.
  • Perform variant annotation, curation, and classification using public and proprietary databases (e.g., ClinVar, COSMIC, gnomAD, OncoKB).
  • Support quality control (QC) and quality assurance (QA) activities by identifying and troubleshooting technical and computational issues.
  • Collaborate with molecular pathologists, clinical scientists, and laboratory personnel to ensure accurate variant interpretation and reporting.
  • Stay up to date with emerging bioinformatics tools, guidelines, and best practices for NGS-based oncology testing .
  • Assist in validation and verification of new assays, software updates, and enhancements to bioinformatics workflows.
  • Participate in CAP/CLIA audits, proficiency testing, and regulatory documentation .
  • Maintain and develop Laboratory Information Management Systems (LIMS) to support efficient clinical sample tracking, data management, and workflow automation.
  • Work closely with laboratory staff to ensure seamless LIMS integration with NGS pipelines and other bioinformatics tools.

Qualifications:

  • PhD in Bioinformatics, Computational Biology, Genomics, Molecular Biology, or a related field, OR MS with at least 3 years of relevant clinical experience .
  • Strong experience with NGS data analysis in a clinical setting , preferably in molecular oncology.
  • Proficiency in Python, R, Perl, Bash, and Linux-based environments for bioinformatics workflows.
  • Familiarity with NGS analysis tools such as GATK, SAMtools, BCFtools, VarDict, Mutect2, Annovar, VEP, and other variant callers/annotators.
  • Experience working with NGS assay validation, quality control metrics, and regulatory compliance (CAP/CLIA/FDA guidelines).
  • Strong knowledge of human genetics, cancer genomics, and clinical variant interpretation (ACMG/AMP/ASCO guidelines).
  • Ability to work in a collaborative, fast-paced clinical laboratory environment with strong analytical and problem-solving skills.

Nice to Have:

  • Prior experience working in a CAP/CLIA-certified clinical laboratory .
  • Knowledge of cloud-based bioinformatics workflows (e.g., AWS, Terra, DNAnexus).Experience with database management, pipeline automation, and high-performance computing (HPC) environments .
  • Understanding of laboratory information management systems (LIMS).
  • Prior involvement in NGS assay development, validation, or FDA submission processes .

Benefits & Perks:

  • Competitive salary and performance-based bonuses
  • Comprehensive healthcare, dental, and vision insurance
  • 401(k) retirement plan with company matching
  • Paid time off and flexible work arrangements
  • Professional development and conference opportunities

Join us in advancing precision oncology through cutting-edge clinical bioinformatics.

Equal Opportunity Statement:

It is the policy of Burning Rock Dx. LLC to provide equal employment and advancement opportunities to all colleagues and applicants for employment without regard to race, color, ethnicity, religion, gender, pregnancy/childbirth, age, national origin, sexual orientation, gender identity or expression, disability or perceived disability, genetic information, citizenship, veteran or military status or a person’s relationship or association with a protected veteran, including spouses and other family members, marital or domestic partner status, or any other category protected by federal, state and/or local laws.

As an equal opportunity employer, Burning Rock Dx LLC is committed to a diverse workforce.

Job Tags

Local area, Flexible hours,

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